Self-reported sleep disturbance and survival in myelodysplastic syndromes

Marlise R Luskin; Angel M Cronin; Robert L Owens; Daniel J DeAngelo; Richard M Stone; Martha Wadleigh; David P Steensma; Gregory A Abel

doi:10.1111/bjh.14573

Self-reported sleep disturbance and survival in myelodysplastic syndromes

Br J Haematol. 2017 May;177(4):562-566. doi: 10.1111/bjh.14573. Epub 2017 Mar 8.

Authors

Marlise R Luskin^{1

2}, Angel M Cronin¹, Robert L Owens³, Daniel J DeAngelo^{1

2}, Richard M Stone^{1

2}, Martha Wadleigh^{1

2}, David P Steensma^{1

2}, Gregory A Abel^{1

2}

Affiliations

¹ Dana-Farber Cancer Institute, Boston, MA, USA.
² Harvard Medical School, Boston, MA, USA.
³ University of California, San Diego, San Diego, CA, USA.

PMID: 28272741
DOI: 10.1111/bjh.14573

Abstract

Neither the prevalence of sleep disturbance nor its association with fatigue and overall survival (OS) are well understood for patients with myelodysplastic syndromes (MDS). New patients at our institution (n = 251; 2006-2014) completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, which includes questions about sleep and fatigue. Fifty-three per cent reported at least 'a little' trouble sleeping. In multivariable models, anaemia and sleep disturbance were associated with fatigue (both P < 0·001). Additionally, in separate models, sleep disturbance (P = 0·002) and fatigue (P = 0·04) both predicted OS. Our data suggest that improving sleep quality may impact MDS-related fatigue and OS.

Keywords: fatigue; myelodysplastic syndromes; overall survival; quality of life; sleep.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Fatigue / etiology
Female
Humans
Male
Middle Aged
Myelodysplastic Syndromes / complications*
Myelodysplastic Syndromes / mortality
Risk Factors
Self Report
Sleep Wake Disorders / complications*
Sleep Wake Disorders / mortality