The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke-associated atopic dermatitis

Affiliations

• ¹ Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
• ² Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
• ³ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; Technical University Bergakademie Freiberg, Freiberg, Germany.
• ⁴ Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; La Jolla Institute for Allergy and Immunology, La Jolla, Calif.
• ⁵ Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; Faculty of Biosciences, Pharmacy and Psychology, Department of Biochemistry, University of Leipzig, Leipzig, Germany.
• ⁶ Department of Environmental Microbiology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
• ⁷ Epiontis GmbH, Berlin, Germany.
• ⁸ Municipal Hospital "St Georg" Children's Hospital, Leipzig, Germany.
• ⁹ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany; Institute of Pharmacy and Molecular Biotechnology (IPMB), and BioQuant Center, University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
• ¹⁰ Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany. Electronic address: [email protected].