Abstract
Two new abscisic acid-type sesquiterpenes (1, 2), and one new ansamycin (3), together with four known ansamycins, namely ansacarbamitocins 4-7, were isolated from the fermentation extract of Amycolatopsis alba DSM 44262. The structures of the new compounds were elucidated to be (E)-3-methyl-5-(2,6,6-trimethyl-3-oxocyclohex-1-enyl)pent-2-enoic acid (1) and (E)-3-methyl-5-(2,6,6-trimethyl-4-oxocyclohex-2-enyl)pent-2-enoic acid (2), and 9-O-methylansacarbamitocin A1 (3), on the basis of comprehensive analysis of spectroscopic data, respectively. The antimicrobial activities were also evaluated for all seven compounds.
Keywords:
Amycolatopsis alba DSM 44262; ansacarbamitocins; ansamycins; antimicrobial activity; sesquiterpenes.
MeSH terms
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Abscisic Acid / chemistry
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Abscisic Acid / isolation & purification*
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Abscisic Acid / pharmacology
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Actinomycetales / chemistry*
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Fatty Acids, Monounsaturated
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Lactams, Macrocyclic / chemistry
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Lactams, Macrocyclic / isolation & purification*
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Lactams, Macrocyclic / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pseudomonas aeruginosa / drug effects
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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Fatty Acids, Monounsaturated
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Lactams, Macrocyclic
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Sesquiterpenes
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pent-2-enoic acid
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Abscisic Acid