Premature Ovarian Failure in French Canadian Leigh Syndrome

Chiraz Ghaddhab; Charles Morin; Catherine Brunel-Guitton; Grant A Mitchell; Guy Van Vliet; Céline Huot

doi:10.1016/j.jpeds.2017.02.008

Premature Ovarian Failure in French Canadian Leigh Syndrome

J Pediatr. 2017 May:184:227-229.e1. doi: 10.1016/j.jpeds.2017.02.008. Epub 2017 Mar 8.

Authors

Chiraz Ghaddhab¹, Charles Morin², Catherine Brunel-Guitton³, Grant A Mitchell³, Guy Van Vliet¹, Céline Huot⁴

Affiliations

¹ Division of Endocrinology and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada.
² Division of Medical Genetics and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada.
³ Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada; Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada.
⁴ Division of Endocrinology and Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Centre de Santé et de Services Sociaux de Chicoutimi, Chicoutimi, Québec, Canada. Electronic address: [email protected].

PMID: 28284481
DOI: 10.1016/j.jpeds.2017.02.008

Abstract

In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases.

Keywords: metabolic acidosis; premature ovarian failure.

Publication types

Case Reports

MeSH terms

Adolescent
Canada
Female
Humans
Leigh Disease / classification
Leigh Disease / complications*
Primary Ovarian Insufficiency / etiology*