A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications

Chem Commun (Camb). 2017 Mar 23;53(25):3555-3558. doi: 10.1039/c6cc09431g.

Abstract

Here, we developed a general strategy for synthesizing homogeneous HA conjugates, and generated homogeneous HA-pNP, HA-biotin, and HA-oroxylin conjugates to investigate the relationships between HA chain length and its diverse biological functions.

MeSH terms

  • Biotin / chemistry
  • Flavonoids / chemistry
  • Hyaluronic Acid / chemical synthesis
  • Hyaluronic Acid / chemistry*
  • Magnetic Resonance Spectroscopy
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Flavonoids
  • 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
  • Biotin
  • Hyaluronic Acid