Mycoplasma genitalium in Spain: prevalence of genital infection and frequency of resistance to macrolides

Enferm Infecc Microbiol Clin (Engl Ed). 2018 Mar;36(3):169-171. doi: 10.1016/j.eimc.2017.01.006. Epub 2017 Mar 11.
[Article in English, Spanish]

Abstract

Introduction: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.

Methods: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.

Results: We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.

Conclusions: The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.

Keywords: Bacterial drug resistance; Epidemiology; Epidemiología; Mycoplasma genitalium; Resistencia bacteriana a antibióticos.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Drug Resistance, Bacterial
  • Female
  • Genital Diseases, Female / drug therapy
  • Genital Diseases, Female / epidemiology*
  • Genital Diseases, Female / microbiology*
  • Genital Diseases, Male / drug therapy
  • Genital Diseases, Male / epidemiology*
  • Genital Diseases, Male / microbiology*
  • Humans
  • Macrolides / pharmacology*
  • Macrolides / therapeutic use
  • Male
  • Mycoplasma Infections / drug therapy
  • Mycoplasma Infections / epidemiology*
  • Mycoplasma Infections / microbiology*
  • Mycoplasma genitalium / drug effects*
  • Prevalence
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Macrolides