Preschoolers' genetic, physiological, and behavioral sensitivity factors moderate links between parenting stress and child internalizing, externalizing, and sleep problems

Dev Psychobiol. 2017 May;59(4):473-485. doi: 10.1002/dev.21510. Epub 2017 Mar 14.

Abstract

This study examined three potential moderators of the relations between maternal parenting stress and preschoolers' adjustment problems: a genetic polymorphism-the short allele of the serotonin transporter (5-HTTLPR, ss/sl allele) gene, a physiological indicator-children's baseline respiratory sinus arrhythmia (RSA), and a behavioral indicator-mothers' reports of children's negative emotionality. A total of 108 mothers (Mage = 30.68 years, SDage = 6.06) reported on their parenting stress as well as their preschoolers' (Mage = 3.50 years, SDage = 0.51, 61% boys) negative emotionality and internalizing, externalizing, and sleep problems. Results indicated that the genetic sensitivity variable functioned according to a differential susceptibility model; however, the results involving physiological and behavioral sensitivity factors were most consistent with a diathesis-stress framework. Implications for prevention and intervention efforts to counter the effects of parenting stress are discussed.

Keywords: 5-HTTLPR; child adjustment; negative emotionality; parenting stress; respiratory sinus arrhythmia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affective Symptoms / genetics
  • Affective Symptoms / physiopathology*
  • Child Behavior / physiology*
  • Child Behavior Disorders / genetics
  • Child Behavior Disorders / physiopathology*
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Parenting*
  • Respiratory Sinus Arrhythmia / genetics
  • Respiratory Sinus Arrhythmia / physiology*
  • Serotonin Plasma Membrane Transport Proteins / genetics
  • Sleep Wake Disorders / genetics
  • Sleep Wake Disorders / physiopathology*
  • Stress, Psychological / genetics
  • Stress, Psychological / physiopathology*

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins