Recent Progress in the Design of Monodisperse, Sequence-Defined Macromolecules

Macromol Rapid Commun. 2017 May;38(9). doi: 10.1002/marc.201600711. Epub 2017 Mar 15.

Abstract

This review describes different synthetic strategies towards sequence-defined, monodisperse macromolecules, which are built up by iterative approaches and lead to linear non-natural polymer structures. The review is divided in three parts: solution phase-, solid phase-, and fluorous- and polymer-tethered approaches. Moreover, synthesis procedures leading to conjugated and non-conjugated macromolecules are considered and discussed in the respective sections. A major focus in the evaluation is the applicability of the different approaches in polymer chemistry. In this context, simple procedures for monomer and oligomer synthesis, overall yields, scalability, purity of the oligomers, and the achievable level of control (side-chains, backbone, stereochemistry) are important benchmarks.

Keywords: conjugated macromolecules; monodisperse; sequence-control; sequence-defined.

Publication types

  • Review

MeSH terms

  • Chemistry / trends*
  • Macromolecular Substances / chemistry
  • Polymers / chemical synthesis*

Substances

  • Macromolecular Substances
  • Polymers