Abstract
Mediator is a conserved and essential coactivator complex broadly required for RNA polymerase II (RNAPII) transcription. Recent genome-wide studies of Mediator binding in budding yeast have revealed new insights into the functions of this critical complex and raised new questions about its role in the regulation of gene expression.
Keywords:
ChEC-seq; Mediator; Pre-initiation complex; RNA polymerase II; TFIID.
MeSH terms
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Gene Expression Regulation, Fungal / physiology*
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Genome, Fungal / physiology*
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Mediator Complex* / genetics
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Mediator Complex* / metabolism
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RNA Polymerase II* / genetics
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RNA Polymerase II* / metabolism
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Schizosaccharomyces pombe Proteins* / genetics
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Schizosaccharomyces pombe Proteins* / metabolism
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Schizosaccharomyces* / genetics
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Schizosaccharomyces* / metabolism
Substances
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Mediator Complex
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Schizosaccharomyces pombe Proteins
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RNA Polymerase II