Biosynthesis of polyphenol-stabilised nanoparticles and assessment of anti-diabetic activity

J Photochem Photobiol B. 2017 Apr:169:96-100. doi: 10.1016/j.jphotobiol.2017.02.017. Epub 2017 Feb 24.

Abstract

Green synthesis of nanoparticles (NPs) is a major developing field. In this study, we utilised Whitania somnifera leaves as a green source to synthesise platinum (Pt) NPs. Synthesised Pt NPs resulted from controlled synthesis of 12nm spherical particles. The synthesised Pt NPs were subjected to anti-diabetic applications resulting in a significant decrease in plasma glucose levels after injecting the Pt NPs into streptozotocin-induced diabetic rats.

Keywords: Anti-diabetic activity; Controlled synthesis; Pt NPs; W. somnifera.

MeSH terms

  • Animals
  • Blood Glucose / drug effects*
  • Diabetes Mellitus, Experimental / drug therapy
  • Drug Stability
  • Green Chemistry Technology
  • Hypoglycemic Agents / chemical synthesis
  • Hypoglycemic Agents / chemistry*
  • Hypoglycemic Agents / pharmacology
  • Metal Nanoparticles / chemistry*
  • Plant Leaves / chemistry
  • Platinum / chemistry
  • Polyphenols*
  • Rats
  • Solanaceae / chemistry

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Polyphenols
  • Platinum