APOL1: a case in point for replacing race with genetics

Girish N Nadkarni; Christina M Wyatt; Barbara Murphy; Michael J Ross

doi:10.1016/j.kint.2017.02.002

APOL1: a case in point for replacing race with genetics

Kidney Int. 2017 Apr;91(4):768-770. doi: 10.1016/j.kint.2017.02.002.

Authors

Girish N Nadkarni¹, Christina M Wyatt², Barbara Murphy², Michael J Ross²

Affiliations

¹ Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: [email protected].
² Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

PMID: 28314574
DOI: 10.1016/j.kint.2017.02.002

Abstract

Ethnicity-specific differences in apolipoprotein L1 (APOL1) polymorphisms are associated with racial disparities in kidney transplantation outcomes. APOL1 genotyping may better help define graft outcome risk pre-transplantation; however, more research is needed.

Publication types

Comment

MeSH terms

Apolipoprotein L1
Apolipoproteins / genetics*
Donor Selection / methods*
Genetic Testing*
Genotype
Graft Survival
Humans
Kidney Transplantation* / adverse effects
Lipoproteins, HDL / genetics*
Phenotype
Polymorphism, Genetic*
Postoperative Complications / ethnology
Postoperative Complications / genetics
Racial Groups*
Risk Assessment
Risk Factors
Tissue Donors*
Treatment Outcome

Substances

APOL1 protein, human
Apolipoprotein L1
Apolipoproteins
Lipoproteins, HDL

Abstract

Publication types

MeSH terms

Substances

Grants and funding