Early onset of cardiometabolic risk factor profiles in drug naïve adolescents and young adults with first-episode schizophrenia

Schizophr Res. 2017 Dec:190:60-62. doi: 10.1016/j.schres.2017.03.004. Epub 2017 Mar 18.

Abstract

Objective and method: We performed a case-control study, which included antipsychotic-naïve first-episode schizophrenia (FES) of adolescents and young adults and general population controls, to investigate the early-onset cardiometabolic risk factors in FES.

Results: FES had more frequent lower HDL-C when compared to controls. However, the distribution of BMI and the frequency of hypercholesterolemia, elevated LDL-C, hypertriglyceridemia in FES were not significantly different to controls.

Conclusions: The results indicated that abnormal HDL-C might be an early-onset event in drug-naïve FES of adolescents and young adults who are unlikely to have other cardiometabolic risks.

Keywords: Cardiometabolic risk factor; Drug naïve; First-episode schizophrenia; High-density lipoprotein cholesterol (HDL-C).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Age of Onset
  • Blood Glucose
  • Body Mass Index
  • Cardiovascular Diseases / complications*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / physiopathology
  • Case-Control Studies
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Female
  • Humans
  • Male
  • Metabolic Diseases / complications*
  • Metabolic Diseases / epidemiology
  • Metabolic Diseases / physiopathology
  • Risk Factors
  • Schizophrenia / complications*
  • Schizophrenia / epidemiology
  • Schizophrenia / physiopathology
  • Young Adult

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL