ILC-poiesis: Making Tissue ILCs from Blood

Jenny Mjösberg; Luca Mazzurana

doi:10.1016/j.immuni.2017.03.002

ILC-poiesis: Making Tissue ILCs from Blood

Immunity. 2017 Mar 21;46(3):344-346. doi: 10.1016/j.immuni.2017.03.002.

Authors

Jenny Mjösberg¹, Luca Mazzurana²

Affiliations

¹ Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, Sweden. Electronic address: [email protected].
² Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 171 77 Stockholm, Sweden.

PMID: 28329700
DOI: 10.1016/j.immuni.2017.03.002

Abstract

The development of human innate lymphoid cells (ILCs) remains poorly characterized. In a recent issue of Cell, Lim et al. show that human peripheral-blood CD117⁺ ILCs harbor ILC precursors (ILCPs) derived from hematopoietic stem cells. Peripheral-blood ILCPs can generate all ILC subsets in vivo and in vitro.

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MeSH terms

Hematopoietic Stem Cells
Humans
Immunity, Innate*
Lymphocytes*