Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors

Michael Bozin; Alastair Lamb; Lydia Johns Putra

doi:10.1016/j.eucr.2017.02.002

Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors

Urol Case Rep. 2017 Mar 21:12:51-53. doi: 10.1016/j.eucr.2017.02.002. eCollection 2017 May.

Authors

Michael Bozin¹, Alastair Lamb², Lydia Johns Putra³

Affiliations

¹ Department of Urology, Ballarat Health Services, Victoria, Australia; Department of Surgical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.
² Department of Surgical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.
³ Department of Urology, Ballarat Health Services, Victoria, Australia.

Abstract

We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of dopamine secreting PPGL compared to classical noradrenaline and adrenaline-secreting PPGL. This includes the risk of peri-operative cardiovascular collapse peri-operatively with alpha/beta blockade, risk of malignancy/recurrence, and associated genetic abnormalities.

Keywords: Dopamine; Paraganglioma; Pheochromocytoma.

Publication types

Case Reports