Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

J Rheumatol. 2017 Jun;44(6):822-826. doi: 10.3899/jrheum.161336. Epub 2017 Apr 1.

Abstract

Objective: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

Methods: A retrospective, multicenter, cohort study.

Results: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

Conclusion: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

Keywords: AUTOIMMUNE CHRONIC UVEITIS; CHILDREN; RELAPSE; THERAPY WITHDRAWAL.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Antirheumatic Agents / therapeutic use*
  • Autoimmune Diseases / drug therapy*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Predictive Value of Tests
  • Recurrence
  • Retrospective Studies
  • Treatment Outcome
  • Uveitis / drug therapy*
  • Withholding Treatment

Substances

  • Antirheumatic Agents