Characterization of the novel HLA-B*49:39 allele identified in a German leukaemia patient

HLA. 2017 Jul;90(1):43-45. doi: 10.1111/tan.13015. Epub 2017 Mar 30.

Authors

P S A Becker¹, S Lindner², S-Z Kim-Wanner¹, G Bug², C Seidl¹

Affiliations

¹ Department of Transplantation Immunology and Immunogenetics, Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany.
² Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

PMID: 28371391
DOI: 10.1111/tan.13015

Abstract

HLA-B*49:39 allele is characterised by 1 amino acid substitution in the alpha 1 domain.

Keywords: HLA-B*49; hematopoietic stem cell transplantation; human leukocyte antigen-B; mismatched related donor; sequence-based typing.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Case Reports

MeSH terms

Alleles*
Amino Acid Substitution
Base Sequence
Codon / chemistry
Exons*
Female
Gene Expression
HLA-B Antigens / genetics*
HLA-B Antigens / immunology
Haplotypes
Hematopoietic Stem Cell Transplantation*
Histocompatibility Testing
Humans
Leukemia / immunology
Leukemia / pathology
Leukemia / therapy*
Male
Nuclear Family
Pedigree
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Sequence Alignment
Sequence Analysis, DNA
Tissue Donors

Substances

Codon
HLA-B Antigens
HLA-B*49 antigen