Cross-talk between the CK2 and AKT signaling pathways in cancer

Maria Ruzzene; Jessika Bertacchini; Alex Toker; Sandra Marmiroli

doi:10.1016/j.jbior.2017.03.002

Cross-talk between the CK2 and AKT signaling pathways in cancer

Adv Biol Regul. 2017 May:64:1-8. doi: 10.1016/j.jbior.2017.03.002. Epub 2017 Mar 28.

Authors

Maria Ruzzene¹, Jessika Bertacchini², Alex Toker³, Sandra Marmiroli⁴

Affiliations

¹ Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy. Electronic address: [email protected].
² Cell Signaling Unit, Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, 41124 Modena, Italy.
³ Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
⁴ Cell Signaling Unit, Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, 41124 Modena, Italy. Electronic address: [email protected].

PMID: 28373060
DOI: 10.1016/j.jbior.2017.03.002

Abstract

CK2 and AKT display a high degree of cross-regulation of their respective functions, both directly, through physical interaction and phosphorylation, and indirectly, through an intense cross-talk of key downstream effectors, ultimately leading to sustained AKT activation. Being CK2 and AKT attractive targets for therapeutic intervention, here we would like to emphasize how AKT and CK2 might influence cell fate through their complex isoform-specific and contextual-dependent cross-talk, to the extent that such functional interplay should be considered when devising therapies that target one or both these key signaling kinases.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Casein Kinase II / antagonists & inhibitors
Casein Kinase II / genetics*
Casein Kinase II / metabolism
Gene Expression Regulation, Neoplastic*
Humans
Molecular Targeted Therapy
Neoplasms / drug therapy
Neoplasms / enzymology
Neoplasms / genetics*
Neoplasms / pathology
Phosphorylation / drug effects
Protein Isoforms / antagonists & inhibitors
Protein Isoforms / genetics
Protein Isoforms / metabolism
Protein Kinase Inhibitors / therapeutic use
Proto-Oncogene Proteins c-akt / antagonists & inhibitors
Proto-Oncogene Proteins c-akt / genetics*
Proto-Oncogene Proteins c-akt / metabolism
Signal Transduction / genetics*

Substances

Antineoplastic Agents
Protein Isoforms
Protein Kinase Inhibitors
Casein Kinase II
Proto-Oncogene Proteins c-akt