Abstract
Functionally active N-methyl-D-aspartate (NMDA) receptors on cat medullary respiratory neurones were revealed by local iontophoretic application of DL-2-amino-7-phosphonoheptanoic acid (AP7). Blockade of NMDA receptors by systemic administration of NMDA antagonists (MK-801, phencyclidine, ketamine, AP7) in vagotomized cats increased the duration of inspiration (Ti) without increasing expiration and caused an apneustic breathing pattern. The increase in Ti which followed systemic MK-801, was accompanied by a shift and complete reversal of early expiratory neuronal discharge in relation to phrenic nerve discharge.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Animals
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / pharmacology
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Cats
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Dibenzocycloheptenes / pharmacology
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Dizocilpine Maleate
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Iontophoresis
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Ketamine / pharmacology
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N-Methylaspartate
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Oxadiazoles / pharmacology
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Phencyclidine / pharmacology
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Phrenic Nerve / drug effects
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Phrenic Nerve / physiology*
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Quisqualic Acid
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / physiology*
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Respiration*
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Respiratory Center / drug effects
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Respiratory Center / metabolism
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Respiratory Center / physiology*
Substances
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Dibenzocycloheptenes
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Oxadiazoles
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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Aspartic Acid
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N-Methylaspartate
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Ketamine
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Dizocilpine Maleate
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Quisqualic Acid
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Phencyclidine