Abstract
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
MeSH terms
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Administration, Topical
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Cations / administration & dosage
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Cations / chemistry
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Cations / pharmacology
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Drug Liberation / drug effects
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Humans
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Hydrogels / administration & dosage
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Hydrogels / chemistry
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Hydrogels / pharmacology*
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Imidazoles / administration & dosage
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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Macromolecular Substances / administration & dosage
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Macromolecular Substances / chemistry
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Macromolecular Substances / pharmacology
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Molecular Structure
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Particle Size
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / pharmacology*
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Skin / drug effects*
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Skin / metabolism
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Skin Absorption / drug effects
Substances
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Cations
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Hydrogels
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Imidazoles
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Macromolecular Substances
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Serine Proteinase Inhibitors