Persistence of a t(11;14)-positive clone in a patient with mantle cell lymphoma for 20 years

Clin Case Rep. 2017 Mar 2;5(4):477-481. doi: 10.1002/ccr3.872. eCollection 2017 Apr.

Abstract

We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow up for such cases.

Keywords: Cyclin D1; Sox11; Splenectomy; mantle cell lymphoma; somatic hypermutation analysis.

Publication types

  • Case Reports