Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli

J Antibiot (Tokyo). 2017 Jul;70(7):859-863. doi: 10.1038/ja.2017.38. Epub 2017 Apr 12.

Authors

Gergana A Vandova^{1

2}, Robert V O'Brien³, Brian Lowry⁴, Thomas F Robbins³, Curt R Fischer^{1

5}, Ronald W Davis^{1

2}, Chaitan Khosla^{3

4

5}, Colin Jb Harvey¹, Maureen E Hillenmeyer¹

Affiliations

¹ Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
² Department of Biochemistry, Stanford University, Palo Alto, CA, USA.
³ Department of Chemistry, Stanford University, Stanford, CA,USA.
⁴ Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
⁵ Stanford ChEM-H Institute, Stanford University, Stanford, CA, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli / metabolism*
Gene Expression Regulation, Enzymologic
Methylmalonyl-CoA Decarboxylase / genetics*
Methylmalonyl-CoA Decarboxylase / metabolism
Polyketide Synthases / genetics
Polyketide Synthases / metabolism
Polyketides / isolation & purification*

Substances

Polyketides
Polyketide Synthases
Methylmalonyl-CoA Decarboxylase

Grants and funding