Late-Onset Alzheimer Disease

Aimee L Pierce; Szofia S Bullain; Claudia H Kawas

doi:10.1016/j.ncl.2017.01.006

Late-Onset Alzheimer Disease

Neurol Clin. 2017 May;35(2):283-293. doi: 10.1016/j.ncl.2017.01.006.

Authors

Aimee L Pierce¹, Szofia S Bullain², Claudia H Kawas³

Affiliations

¹ Department of Neurology and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1100 Medical Plaza Drive, Irvine, CA 92697, USA. Electronic address: [email protected].
² Department of Neurology and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697, USA.
³ Departments of Neurology, Neurobiology & Behavior, Epidemiology, and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1121 Gillespie, Irvine, CA 92697, USA.

PMID: 28410660
DOI: 10.1016/j.ncl.2017.01.006

Abstract

The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.

Keywords: Alzheimer disease; Dementia; Late-onset; Oldest-old; Pathology.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Age of Onset
Aging*
Alzheimer Disease / pathology*
Alzheimer Disease / physiopathology*
Dementia / pathology
Dementia / physiopathology*
Humans

Abstract

Publication types

MeSH terms

Grants and funding