Advanced penile cancer with iliac lymph node involvement treated with radiation and concurrent gemcitabine

Cancer Radiother. 2017 Apr;21(2):134-137. doi: 10.1016/j.canrad.2016.10.003. Epub 2017 Apr 12.

Abstract

Penile cancer is a rare entity with only 2000 new cases a year in the United States. Even though early stage penile cancer has an excellent prognosis, patients with positive pelvic lymph nodes have an overall 5-year survival rate under 10%. There is no consensus for the management of pelvic node-positive patients, although most guidelines are in favour of pelvic lymph node dissection for patients with two or more positive nodes, followed by adjuvant chemotherapy. We describe here the case of a patient with numerous metastatic lymph nodes at diagnosis, treated with chemoradiation (66Gy with concurrent gemcitabine) after failure of first-line chemotherapy and still alive and disease-free 7 years after diagnosis.

Keywords: Chemoradiotherapy; Chimioradiothérapie; Penile neoplasms; Radiotherapy; Radiothérapie; Tumeurs du pénis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Combined Modality Therapy
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / therapeutic use
  • Gemcitabine
  • Humans
  • Lymphatic Metastasis
  • Male
  • Pelvis
  • Penile Neoplasms / drug therapy*
  • Penile Neoplasms / pathology
  • Penile Neoplasms / radiotherapy*

Substances

  • Antimetabolites, Antineoplastic
  • Deoxycytidine
  • Gemcitabine