A case of CD30+ ALK1- anaplastic large cell lymphoma resembling acute disseminated encephalomyelitis

Mult Scler Relat Disord. 2017 Apr:13:119-121. doi: 10.1016/j.msard.2017.03.003. Epub 2017 Mar 6.

Abstract

Central nervous system involvement is an uncommon complication of systemic non-Hodgkin lymphomas. The majority of these cases concern B-cell lymphomas. We report a case of systemic T-cell anaplastic large cell lymphoma CD30+ ALK- with CNS involvement at the time of diagnosis and unusual MRI characteristics resembling acute disseminated encephalomyelitis.

Keywords: ALK1-; Acute disseminated encephalomyelitis; Anaplastic large cell lymphoma; CD30+; T-cell lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Anaplastic Lymphoma Kinase
  • Brain / diagnostic imaging
  • Brain / pathology
  • Encephalomyelitis, Acute Disseminated / complications*
  • Encephalomyelitis, Acute Disseminated / diagnostic imaging
  • Encephalomyelitis, Acute Disseminated / immunology
  • Encephalomyelitis, Acute Disseminated / pathology
  • Humans
  • Ki-1 Antigen / immunology
  • Lymphoma, Large-Cell, Anaplastic / complications*
  • Lymphoma, Large-Cell, Anaplastic / diagnostic imaging
  • Lymphoma, Large-Cell, Anaplastic / immunology
  • Lymphoma, Large-Cell, Anaplastic / pathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Receptor Protein-Tyrosine Kinases / immunology

Substances

  • Ki-1 Antigen
  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Receptor Protein-Tyrosine Kinases