Brain Lesions in Children with Unilateral Spastic Cerebral Palsy

Med Arch. 2017 Feb;71(1):7-11. doi: 10.5455/medarh.2017.71.7-11. Epub 2017 Feb 5.

Abstract

Introduction: Unilateral spastic cerebral palsy (US CP) is the second most common subtype of cerebral palsy.

Aim: The aim of the study was to analyze neuroimaging findings in children with unilateral spastic cerebral palsy.

Material and methods: The study was hospital based, which has included 106 patients with US CP (boys 72/girls 34, term 82/preterm 24). Neuroimaging findings were classified into 5 groups: Brain maldevelopment, predominant white matter injury, predominant gray matter injury, non specific findings and normal neuroimaging findings.

Results: Predominant white matter lesions where the most frequent (48/106,45.28%; term 35/preterm 13), without statistically significant difference between term and preterm born children (x2=0.4357; p=0.490517). Predominant gray matter lesions had 32/106 children, 30.19%; (term 25/preterm 7, without statistically significant difference between term and preterm born children (x2=0.902; p=0.9862). Brain malformations had 10/106 children, 9.43%, and all of them were term born. Other finding had 2/106 children, 1.89%, both of them were term born. Normal neuroimaging findings were present in14/106 patients (13.21%).

Conclusion: Neuroimaging may help to understand morphological background of motor impairment in children with US CP. Periventricular white matter lesions were the most frequent, then gray matter lesions.

Keywords: Unilateral spastic cerebral palsy; brain lesions; child.

MeSH terms

  • Brain / pathology*
  • Cerebral Palsy / diagnostic imaging
  • Cerebral Palsy / pathology*
  • Cerebral Palsy / physiopathology
  • Child
  • Child, Preschool
  • Female
  • Functional Laterality / physiology
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging*
  • Male
  • Motor Cortex / pathology
  • Neuroimaging*
  • Premature Birth
  • Term Birth
  • White Matter / pathology