Does endothelial tetrahydrobiopterin control the endothelial NO synthase coupling state in arterial resistance arteries?

Br J Pharmacol. 2017 Jul;174(14):2422-2424. doi: 10.1111/bph.13827. Epub 2017 Jun 4.

Abstract

This article is a Commentary on Chuaiphichai S, Crabtree MJ, McNeill E, Hale AB, Trelfa L, Channon KM et al. (2017). A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice. Br J Pharmacol 174: 657-671. https://doi.org/10.1111/bph.13728.

MeSH terms

  • Animals
  • Arteries / drug effects*
  • Arteries / metabolism
  • Biopterins / analogs & derivatives*
  • Biopterins / pharmacology
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / metabolism
  • Humans
  • Mice
  • Nitric Oxide Synthase Type III / antagonists & inhibitors*
  • Nitric Oxide Synthase Type III / metabolism

Substances

  • Biopterins
  • Nitric Oxide Synthase Type III
  • sapropterin