A Determined "Hesitation" on H3K27me3 Empowers Stem Cells to Differentiate

Xin Huang; Jianlong Wang

doi:10.1016/j.molcel.2017.04.003

A Determined "Hesitation" on H3K27me3 Empowers Stem Cells to Differentiate

Mol Cell. 2017 Apr 20;66(2):165-166. doi: 10.1016/j.molcel.2017.04.003.

Authors

Xin Huang¹, Jianlong Wang²

Affiliations

¹ The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: [email protected].

PMID: 28431228
DOI: 10.1016/j.molcel.2017.04.003

Abstract

To uncover the precise mechanisms coordinating proliferation and fate choice of stem cells, in this issue of Molecular Cell and in an accompanying paper in Cell Reports, Mazo and colleagues (Petruk et al. 2017a, 2017b) reveal that delayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in stem cell differentiation.

Keywords: DNA replication; ESC; H3K27me3; HPC; KDM6A; KDM6B; PRC2; UTX; cell cycle; stem cell differentiation.

MeSH terms

Cell Differentiation / genetics*
Humans
Transcription Factors*

Substances

Transcription Factors