Who and how in the regulation of mitochondrial cristae shape and function

R Quintana-Cabrera; A Mehrotra; G Rigoni; M E Soriano

doi:10.1016/j.bbrc.2017.04.088

Who and how in the regulation of mitochondrial cristae shape and function

Biochem Biophys Res Commun. 2018 May 27;500(1):94-101. doi: 10.1016/j.bbrc.2017.04.088. Epub 2017 Apr 21.

Authors

R Quintana-Cabrera¹, A Mehrotra², G Rigoni², M E Soriano³

Affiliations

¹ Department of Biology, University of Padova, Padova, 35121, Italy; Venetian Institute of Molecular Medicine, Padova 35129, Italy.
² Department of Biology, University of Padova, Padova, 35121, Italy.
³ Department of Biology, University of Padova, Padova, 35121, Italy. Electronic address: [email protected].

PMID: 28438601
DOI: 10.1016/j.bbrc.2017.04.088

Abstract

Mitochondrial adaptation to different physiological conditions highly relies on the regulation of mitochondrial ultrastructure, particularly at the level of cristae compartment. Cristae represent the membrane hub where most of the respiratory complexes embed to account for OXPHOS and energy production in the form of adenosine triphosphate (ATP). Changes in cristae number and shape define the respiratory capacity as well as cell viability. The identification of key regulators of cristae morphology and the understanding of their contribution to the mitochondrial ultrastructure and function have become an strategic goal to understand mitochondrial disorders and to exploit as therapeutic targets. This review summarizes the known regulators of cristae ultrastructure and discusses their contribution and implications for mitochondrial dysfunction.

Keywords: ATP synthase dimers; Cristae ultrastructure; MICOS; Mitochondria; OPA1.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine Triphosphate / biosynthesis
Cell Survival
Electron Transport Chain Complex Proteins / genetics
Electron Transport Chain Complex Proteins / metabolism*
Eukaryotic Cells / metabolism*
Eukaryotic Cells / ultrastructure
GTP Phosphohydrolases / genetics
GTP Phosphohydrolases / metabolism
Gene Expression Regulation
Humans
Mitochondria / metabolism*
Mitochondria / ultrastructure
Mitochondrial Membrane Transport Proteins / genetics
Mitochondrial Membrane Transport Proteins / metabolism*
Mitochondrial Membranes / metabolism*
Mitochondrial Membranes / ultrastructure
Mitochondrial Proton-Translocating ATPases / genetics
Mitochondrial Proton-Translocating ATPases / metabolism*
Organelle Shape / physiology
Oxidative Phosphorylation
Protein Multimerization
Signal Transduction

Substances

Electron Transport Chain Complex Proteins
Mitochondrial Membrane Transport Proteins
Adenosine Triphosphate
GTP Phosphohydrolases
OPA1 protein, human
Mitochondrial Proton-Translocating ATPases