Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models

Antimicrob Agents Chemother. 2017 Jun 27;61(7):e02554-16. doi: 10.1128/AAC.02554-16. Print 2017 Jul.

Abstract

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

Keywords: miconazole; onychomycosis; topical.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacokinetics*
  • Antifungal Agents / therapeutic use
  • Cattle
  • Hoof and Claw / microbiology
  • Humans
  • Miconazole / administration & dosage
  • Miconazole / pharmacokinetics*
  • Miconazole / therapeutic use
  • Nails / microbiology*
  • Onychomycosis / drug therapy*
  • Onychomycosis / microbiology

Substances

  • Antifungal Agents
  • Miconazole