Transfer of KPC-2 carbapenemase from Klebsiella pneumoniae to Enterobacter cloacae in a patient receiving meropenem therapy

Evelin Rodrigues Martins; Cássia Fernanda Estofolete; Andressa Batista Zequini; Louise Cerdeira; Doroti de Oliveira Garcia; Maria Fernanda Campagnari Bueno; Gabriela Rodrigues Francisco; Leonardo Neves de Andrade; Ana Lúcia da Costa Darini; Fernanda Modesto Tolentino; Tiago Casella; Nilton Lincopan; Mara Corrêa Lelles Nogueira

doi:10.1016/j.diagmicrobio.2017.04.004

Transfer of KPC-2 carbapenemase from Klebsiella pneumoniae to Enterobacter cloacae in a patient receiving meropenem therapy

Diagn Microbiol Infect Dis. 2017 Jul;88(3):287-289. doi: 10.1016/j.diagmicrobio.2017.04.004. Epub 2017 Apr 12.

Authors

Affiliations

¹ Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil. Electronic address: [email protected].
² Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil; Hospital de Base de São José do Rio Preto, São José do Rio Preto, Brazil. Electronic address: [email protected].
³ Hospital de Base de São José do Rio Preto, São José do Rio Preto, Brazil. Electronic address: [email protected].
⁴ Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil. Electronic address: [email protected].
⁵ Instituto Adolfo Lutz, São Paulo, Brazil. Electronic address: [email protected].
⁶ Instituto Adolfo Lutz, São Paulo, Brazil. Electronic address: [email protected].
⁷ Instituto Adolfo Lutz, São Paulo, Brazil. Electronic address: [email protected].
⁸ Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Ribeirão Preto, Brazil. Electronic address: [email protected].
⁹ Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Ribeirão Preto, Brazil. Electronic address: [email protected].
¹⁰ Instituto Adolfo Lutz, São José do Rio Preto, Brazil; Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, Brazil. Electronic address: [email protected].
¹¹ Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil; Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, Brazil. Electronic address: [email protected].
¹² Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil; Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil. Electronic address: [email protected].
¹³ Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil; Hospital de Base de São José do Rio Preto, São José do Rio Preto, Brazil. Electronic address: [email protected].

PMID: 28442305
DOI: 10.1016/j.diagmicrobio.2017.04.004

Abstract

The horizontal transfer of a plasmid bearing the bla_KPC-2 gene from K. pneumoniae to E. cloacae infecting the respiratory tract of a patient during meropenem therapy was elucidated. This finding is particularly worrisome, since these drugs are of last resort for multidrug-resistant Gram-negative pathogens.

Keywords: Enterobacter cloacae; Horizontal gene transfer; Klebsiella pneumoniae; Plasmid; bla(KPC-2).

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Enterobacter cloacae / genetics*
Gene Transfer, Horizontal*
Genes, Bacterial
Humans
Klebsiella Infections / drug therapy*
Klebsiella Infections / microbiology
Klebsiella pneumoniae / genetics*
Male
Meropenem
Middle Aged
Plasmids / analysis
Respiratory Tract Infections / drug therapy
Respiratory Tract Infections / microbiology
Thienamycins / therapeutic use*
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Thienamycins
beta-lactamase KPC-2
beta-Lactamases
Meropenem