Patients With Diabetes and Chronic Liver Disease Are at Increased Risk for Overall Mortality: A Population Study From the United States

Maria Stepanova; Stephen Clement; Robert Wong; Sammy Saab; Aijaz Ahmed; Zobair M Younossi

doi:10.2337/cd16-0018

Patients With Diabetes and Chronic Liver Disease Are at Increased Risk for Overall Mortality: A Population Study From the United States

Clin Diabetes. 2017 Apr;35(2):79-83. doi: 10.2337/cd16-0018.

Authors

Maria Stepanova^{1

2}, Stephen Clement³, Robert Wong⁴, Sammy Saab⁵, Aijaz Ahmed^{6

7}, Zobair M Younossi^{1

2

8}

Affiliations

¹ Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA.
² Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA.
³ Section of Endocrinology, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA.
⁴ Division of Gastroenterology and Hepatology, Alameda Health System-Highland Hospital Campus, Oakland, CA.
⁵ Departments of Medicine and Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.
⁶ Department of Surgery, Stanford University School of Medicine, Stanford, CA.
⁷ Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
⁸ Department of Medicine, Inova Fairfax Hospital, Falls Church, VA.

Abstract

IN BRIEF Chronic liver disease (CLD) and type 2 diabetes have both been linked to increased morbidity and mortality. In this study, the impact of CLD and diabetes on all-cause mortality was quantified at the population level using U.S. population data. Both type 2 diabetes and CLD were found to be independently associated with increased mortality (age-adjusted hazard ratio [aHR] 1.98 and 1.37 for diabetes and CLD, respectively), and having both diabetes and CLD substantially increased the risk of mortality (aHR 2.41).