Abstract
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Female
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Ferric Compounds / chemistry*
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Folic Acid / chemistry
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Gold / chemistry*
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Humans
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Image Processing, Computer-Assisted / methods
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Magnetic Resonance Imaging / methods*
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Magnetite Nanoparticles / administration & dosage*
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Magnetite Nanoparticles / chemistry
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Micelles
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Multimodal Imaging / methods
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology*
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Photoacoustic Techniques / methods*
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Polymers / chemistry*
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Silicon Dioxide / chemistry*
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Tumor Cells, Cultured
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Xenograft Model Antitumor Assays
Substances
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Ferric Compounds
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Magnetite Nanoparticles
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Micelles
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Polymers
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ferric oxide
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Gold
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Silicon Dioxide
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Folic Acid