Percutaneous revascularization in patients treated with thoracic radiation for cancer

Am Heart J. 2017 May:187:98-103. doi: 10.1016/j.ahj.2017.02.014. Epub 2017 Feb 20.

Abstract

Objectives: To assess coronary revascularization outcomes in patients with previous thoracic radiation therapy (XRT).

Background: Previous chest radiation has been reported to adversely affect long term survival in patients with coronary disease treated with percutaneous coronary interventions (PCI).

Methods: Retrospective, single center cohort study of patients previously treated with thoracic radiation and PCI. Patients were propensity matched against control patients without radiation undergoing revascularization during the same time period.

Results: We identified 116 patients with radiation followed by PCI (XRT-PCI group) and 408 controls. Acute procedural complications were similar between groups. There were no differences in all-cause and cardiac mortality between groups (all-cause mortality HR 1.31, P=.078; cardiac mortality 0.78, P=.49).

Conclusion: Patients with prior thoracic radiation and coronary disease treated with PCI have similar procedural complications and long term mortality when compared to control subjects.

MeSH terms

  • Aged
  • Cause of Death
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / surgery*
  • Female
  • Humans
  • Male
  • Percutaneous Coronary Intervention*
  • Propensity Score
  • Radiotherapy / adverse effects
  • Retrospective Studies
  • Thoracic Neoplasms / radiotherapy*
  • Treatment Outcome