Clinicopathological Features of Thymoma with Ring Calcification: Case Reports

Ann Thorac Cardiovasc Surg. 2017 Oct 20;23(5):256-261. doi: 10.5761/atcs.cr.16-00247. Epub 2017 May 1.

Abstract

Thymomas with ring calcifications are very rare and quaint style. Herein, we presented our three cases of thymomas with ring calcifications and reviewed totally 10 cases including 7 cases of previous English literatures. The median age was 53 years. Myasthenia gravis was a complication in 40%. The median maximal diameter was 50 mm. They were diagnosed as pathological type B or had type B component. Based on World Health Organization (WHO) classification, 20%, 60%, and 20% cases were stage I, stage II, and stage III, respectively. Seven ring calcifications were within tumors (inner type) and two cases were outside tumors (outer type). The other had a thymoma arising in the calcic wall of a calcified thymic cyst (miscellaneous type). Four other anterior mediastinal tumors with ring calcification had been reported. We need pathological examinations for a definitive diagnosis. Surgeons should plan surgery because of the possibility of invasive thymomas, or other malignant tumors.

Keywords: calcification; egg shell; ring; thymoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Calcinosis / diagnostic imaging
  • Calcinosis / pathology*
  • Calcinosis / surgery
  • Child
  • Female
  • Humans
  • Male
  • Mediastinal Cyst / diagnostic imaging
  • Mediastinal Cyst / pathology*
  • Mediastinal Cyst / surgery
  • Middle Aged
  • Neoplasm Staging
  • Thymectomy
  • Thymoma / diagnostic imaging
  • Thymoma / pathology*
  • Thymoma / surgery
  • Thyroid Neoplasms / diagnostic imaging
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Tumor Burden