Objective: Obesity is one of the risk factors for gout. The aim of the present study was to evaluate clinical characteristics of gout patients with different BMI. Methods: A total of 5 104 patients with gout were enrolled and divided into three groups according to the BMI. The clinical information was collected and relevant biochemical indices were detected. SPSS software was applied for the statistical analyses. Results: There were significant differences in the ratios of gender, regular exercise, hypertension, tophus, renal insufficiency, hyperlipidemia, impaired glucose metabolism, liver dysfunction among the three groups (all P<0.01). The onset age in overweight [45(36, 55) years] and obese subjects [40(31, 50) years] were earlier than that of the normal weight subjects [50(38, 61) years]. Moreover, waist circumstances [103(99, 108) cm and 94 (90, 98) cm vs 87 (82, 91) cm], systolic pressure [130 (120, 145) mmHg (1 mmHg=0.133 kPa)and 130(120, 140)mmHg vs 128(115, 140) mmHg], diastolic pressure [90 (80, 100) mmHg and 85 (80, 92) mmHg vs 80 (79, 90) mmHg], fasting blood glucose [5.77 (5.30, 6.44) mmol/L and 5.65 (5.19, 6.26) mmol/L vs 5.55 (5.10, 6.15) mmol/L], TG [2.10 (1.46, 3.04) mmol/L and 1.88 (1.35, 2.78) mmol/L vs 1.52 (1.07, 2.39) mmol/L], TC [5.20 (4.55, 5.93) mmol/L and 5.07 (4.46, 5.75) mmol/L vs 4.95 (4.27, 5.65) mmol/L], serum uric acid [483(418, 552) μmol/L and 461(395, 524) μmol/L vs 440 (368, 517) μmol/L], ALT [30 (21, 46) U/L and 25 (18, 36) U/L vs 21 (14, 29) U/L], AST [21(17, 28) U/L and 20 (17, 26) U/L vs 20 (6, 25) U/L], the number of joints involved [2(1, 3)joints and 2(1, 2) joints vs 1(1, 2) joints] in the overweight and obese groups were higher than those in the normal weight group ( all P<0.01). There were no statistical differences in family history, involvement of upper limb joints, kidney stones and coronary heart disease among the three groups (all P>0.05). Conclusions: Obesity is associated with an earlier age of gout onset.With the increase of BMI, the blood pressures, glucose, lipid, serum uric acid, liver transaminase levels and the number of involved joints increased gradually. Cautions should be taken in treating patients with different BMI.
目的： 探讨不同BMI痛风患者临床特点，为痛风的个体化治疗提供临床依据。 方法： 选取2011年4月—2016年3月在青岛大学附属医院痛风临床医学中心门诊及住院的痛风患者5 104例，根据BMI分为非超重组、超重组、肥胖组，分别采集其临床资料并检测相关生化指标，应用SPSS软件进行统计学分析。 结果： 3组患者在男性、规律运动、合并痛风石、肾功能不全、高血压、高血脂、糖代谢异常、肝功能异常比例方面差异有统计学意义(P<0.01)；肥胖组及超重组患者痛风发病年龄明显小于非超重组[40(31，50)岁，45(36，55)岁比50(38，61)岁]；肥胖组及超重组患者的腰围[103(99，108) cm，94(90，98) cm比87(82，91) cm]、收缩压[130(120，145) mmHg(1 mmHg＝0.133 kPa)，130(120，140) mmHg比128(115，140) mmHg]、舒张压[90(80，100) mmHg，85(80，92) mmHg比80(79，90) mmHg]、空腹血糖[5.77(5.30，6.44) mmol/L，5.65(5.19，6.26) mmol/L比5.55(5.10，6.15) mmol/L]、TG[2.10(1.46，3.04) mmol/L，1.88(1.35，2.78) mmol/L比1.52(1.07，2.39) mmol/L]、TC[5.20(4.55，5.93) mmol/L, 5.07(4.46，5.75) mmol/L比4.95(4.27，5.65) mmol/L]、血尿酸[483(418，552) μmol/L，461(395，524) μmol/L比440(368，517) μmol/L]、 ALT[30(21，46) U/L，25(18，36) U/L比21(14，29) U/L]、AST[21(17，28) U/L，20(17，26) U/L比20(16，25) U/L]、受累关节数目[2(1，3)个，2(1，2)个比1(1，2)个]明显高于非超重组(P<0.01)；但非超重组、超重组、肥胖组患者在合并痛风家族史、肾结石、冠心病、上肢关节受累比例差异无统计学意义(P>0.05)。 结论： 随着BMI的增加，痛风发病年龄提早，血压、血糖、血脂、血尿酸、肝脏转氨酶水平逐渐升高，受累关节数目逐渐增多，临床上应注意个体化治疗。.
Keywords: Body mass index; Clinical characteristic; Gout.