Role of transient receptor potential melastatin type 7 channel in gastric cancer

Byung Joo Kim; Chansik Hong

doi:10.1016/j.imr.2016.04.004

Role of transient receptor potential melastatin type 7 channel in gastric cancer

Integr Med Res. 2016 Jun;5(2):124-130. doi: 10.1016/j.imr.2016.04.004. Epub 2016 Apr 11.

Authors

Byung Joo Kim^{1

2}, Chansik Hong³

Affiliations

¹ Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan, Korea.
² Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan, Korea.
³ Department of Physiology, Seoul National University, College of Medicine, Seoul, Korea.

Abstract

Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg²⁺ and Ca²⁺. It contains a channel and a kinase domain. Recent studies indicate that activation of TRPM7 plays an important role in the growth and survival of gastric cancer cells. In this review, we describe and discuss the findings of recent studies that have provided novel insights of the relation between TRPM7 and gastric cancer.

Keywords: TRPM7; gastric cancer; ion channel; proliferation; transient receptor potential melastatin 7.

Publication types

Review