Abstract
The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Differentiation, T-Lymphocyte* / immunology
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Cytoplasm / immunology
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HIV / immunology*
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HIV Envelope Protein gp120
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Humans
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Immunosuppressive Agents / physiology*
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Interleukin-2 / biosynthesis
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Mice
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Phenotype
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Retroviridae Proteins / physiology*
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T-Lymphocytes / classification
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T-Lymphocytes / metabolism*
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Viral Envelope Proteins / physiology*
Substances
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Antigens, Differentiation, T-Lymphocyte
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HIV Envelope Protein gp120
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Immunosuppressive Agents
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Interleukin-2
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Retroviridae Proteins
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Viral Envelope Proteins