Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging

Xiao Tian; Andrei Seluanov; Vera Gorbunova

doi:10.1016/j.cmet.2017.04.022

Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging

Cell Metab. 2017 May 2;25(5):991-992. doi: 10.1016/j.cmet.2017.04.022.

Authors

Xiao Tian¹, Andrei Seluanov¹, Vera Gorbunova²

Affiliations

¹ Department of Biology, University of Rochester, Rochester, NY 14627, USA.
² Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address: [email protected].

PMID: 28467943
DOI: 10.1016/j.cmet.2017.04.022

Abstract

DNA-dependent protein kinase (DNA-PK), a central player in DNA double-strand break (DSB) repair, shows emerging roles in metabolic regulation. In this issue of Cell Metabolism, Park et al. (2017) elucidate a molecular mechanism whereby DNA-PK negatively regulates AMPK, contributing to metabolic and fitness decline during aging.

MeSH terms

AMP-Activated Protein Kinase Kinases
Aging*
Animals
DNA Breaks, Double-Stranded
DNA Damage*
DNA-Activated Protein Kinase / metabolism*
HSP90 Heat-Shock Proteins / metabolism
Humans
Metabolic Networks and Pathways
Protein Kinases / metabolism

Substances

HSP90 Heat-Shock Proteins
Protein Kinases
DNA-Activated Protein Kinase
AMP-Activated Protein Kinase Kinases

Abstract

MeSH terms

Substances

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