Re-evaluation of the hydrogen stable isotopic composition of keratin calibration standards for wildlife and forensic science applications

Rapid Commun Mass Spectrom. 2017 Jul 30;31(14):1193-1203. doi: 10.1002/rcm.7893.

Abstract

Rationale: Determination of non-exchangeable hydrogen isotopic compositions (δ2 H values) of bulk complex organic materials is difficult due to uncontrolled H isotope exchange between the organic material and ambient water vapor. A number of calibration keratinous materials with carefully measured hydrogen isotopic compositions of the non-exchangeable fraction were proposed to enable stable isotope laboratories to normalize their 2 H measurements. However, it was recently reported that high-temperature carbon-reactor methods for measuring the hydrogen isotopic composition of nitrogenous organic materials is biased by the production of HCN in the reactor. As a result, the reported values of these calibration materials needed to be re-evaluated.

Methods: We evaluated the non-exchangeable δ2 HVSMOW values of keratins EC1 (CBS) and EC2 (KHS), USGS hair standards, and a range of other nitrogenous widely used organic laboratory calibration materials (collagen and chitin) using pre-treatment with a preparation device designed to eliminate residual moisture and quantify exchangeable H.

Results: The revised non-exchangeable δ2 HVSMOW values of EC-1 (CBS) and EC-2 (KHS) keratin standard materials were -157.0 ± 0.9 and -35.3 ± 1.1 ‰, respectively. The revised values of USGS42 and USGS43 were -72.2 ± 0.9 and -44.2 ± 1.0 ‰, respectively, in excellent agreement with previous results.

Conclusions: For routine H isotope analyses, with proper sample pre-treatment, we show that the Comparative Equilibration approach can provide accurate and reproducible non-exchangeable δ2 H values among laboratories regardless of the reactor type used. © 2017 Her Majesty the Queen in Right of Canada Rapid Communications in Mass Spectrometry © 2017 John Wiley & Sons Ltd. Reproduced with the permission of the Environment and Climate Change Canada.

MeSH terms

  • Animals
  • Animals, Wild
  • Calibration
  • Forensic Sciences / standards*
  • Hair / chemistry
  • Humans
  • Hydrogen / analysis*
  • Hydrogen / chemistry
  • Isotope Labeling
  • Keratins / analysis*
  • Keratins / chemistry
  • Mass Spectrometry / standards*
  • Reference Standards

Substances

  • Keratins
  • Hydrogen