Gotta Have GATA for Human Pancreas Development

David S Lorberbaum; Lori Sussel

doi:10.1016/j.stem.2017.04.004

Gotta Have GATA for Human Pancreas Development

Cell Stem Cell. 2017 May 4;20(5):577-579. doi: 10.1016/j.stem.2017.04.004.

Authors

David S Lorberbaum¹, Lori Sussel²

Affiliations

¹ Barbara Davis Center, University of Colorado Anschutz Medical Center, Aurora CO 80206, USA.
² Barbara Davis Center, University of Colorado Anschutz Medical Center, Aurora CO 80206, USA. Electronic address: [email protected].

PMID: 28475878
DOI: 10.1016/j.stem.2017.04.004

Abstract

Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports utilize hPSCs to characterize GATA6 function during human pancreas development. One functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation, but it is inadequate for functional β cell differentiation.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation / genetics
Cell Differentiation / physiology
GATA6 Transcription Factor / genetics
GATA6 Transcription Factor / metabolism*
Gene Expression Regulation, Developmental / genetics
Gene Expression Regulation, Developmental / physiology
Humans
Insulin-Secreting Cells / cytology
Insulin-Secreting Cells / metabolism
Mice
Mutation, Missense / genetics
Pancreas / embryology*
Pancreas / metabolism*
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / metabolism

Substances

GATA6 Transcription Factor