Hematopoiesis: Reconciling Historic Controversies about the Niche

Ninib Baryawno; Nicolas Severe; David T Scadden

doi:10.1016/j.stem.2017.03.025

Hematopoiesis: Reconciling Historic Controversies about the Niche

Cell Stem Cell. 2017 May 4;20(5):590-592. doi: 10.1016/j.stem.2017.03.025.

Authors

Ninib Baryawno¹, Nicolas Severe¹, David T Scadden²

Affiliations

¹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: [email protected].

PMID: 28475884
DOI: 10.1016/j.stem.2017.03.025

Abstract

The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.

MeSH terms

Animals
Cell Differentiation / genetics
Cell Differentiation / physiology
Hematopoiesis / genetics
Hematopoiesis / physiology*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism
Mice
RNA, Messenger / genetics
Stem Cell Niche / genetics
Stem Cell Niche / physiology*

Substances

RNA, Messenger