Abstract
Centers for Disease Control and Prevention and sequencing-based treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency virus and syphilis co-infected patients during 2014 to 2015 in Antwerp, Belgium. Twenty-nine (40.3%) isolates were polymerase chain reaction positive for Treponema pallidum, and all tested were macrolide-resistant. Four genotypes were identified by sequencing-based typing including two new genotypes, U4NR8 and SU9R8, whereas enhanced Centers for Disease Control and Prevention typing revealed 7 subtypes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology
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Belgium / epidemiology
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Drug Resistance, Bacterial / genetics
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Female
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Genotype
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HIV Seropositivity / complications
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HIV Seropositivity / epidemiology
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HIV Seropositivity / microbiology*
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Humans
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Macrolides / pharmacology
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Male
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Middle Aged
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Molecular Typing*
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Point Mutation
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Polymorphism, Restriction Fragment Length
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RNA, Ribosomal, 23S / genetics
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Syphilis / complications
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Syphilis / drug therapy
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Syphilis / epidemiology
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Syphilis / microbiology*
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Treponema pallidum / classification*
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Treponema pallidum / genetics*
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Treponema pallidum / isolation & purification
Substances
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Anti-Bacterial Agents
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Macrolides
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RNA, Ribosomal, 23S