Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy in the Management of Colorectal Peritoneal Metastasis

Surg Clin North Am. 2017 Jun;97(3):671-682. doi: 10.1016/j.suc.2017.01.013.

Abstract

Historically, patients with peritoneal carcinomatosis secondary to colorectal cancer have a poor overall prognosis. Recent data support the use of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS + HIPEC) to specifically address the peritoneal disease. Retrospective studies on CRS + HIPEC have been promising, showing significant improvements in OS compared with systemic chemotherapy alone. However, CRS + HIPEC carries morbidity similar to other advance oncology procedures such as liver resection and pancreatoduonectomy. It is hoped that ongoing clinical trials will clarify its role in the treatment of patients with peritoneal metastatic colorectal cancer.

Keywords: CC score; Cytoreductive surgery (CRS); Hyperthermic intraperitoneal chemotherapy (HIPEC); Intraperitoneal chemotherapy (IP); Peritoneal carcinoma index (PCI); Peritoneal metastasis (PM); R score.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Colorectal Neoplasms / pathology*
  • Combined Modality Therapy
  • Cytoreduction Surgical Procedures*
  • Humans
  • Hyperthermia, Induced*
  • Peritoneal Neoplasms / secondary*
  • Peritoneal Neoplasms / therapy
  • Prognosis

Substances

  • Antineoplastic Agents