[Carney's triad. Apropos of a case of recurrent gastric leiomyosarcoma and bilateral pulmonary chondroma]

Radiol Med. 1988 Dec;76(6):577-9.
[Article in Italian]

Abstract

Carney's triad is a rare syndrome characterized by gastric leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. Twenty-seven cases are reported in literature: the most commonly observed neoplasm is gastric leiomyosarcoma (26/27) followed by lung tumor (22/27), and gastric paraganglioma (15/27). Three patients bearing a gastric leiomyosarcoma developed liver metastases, and 6 had a local recurrence after some years. The occurrence of paraganglioma makes the prognosis worse: 4 deaths from local infiltration, metastases or severe hypertension. The triad only occurred in 9/27 cases, mostly young female patients. A common embryologic origin is difficult to assess. The case of a young female patient with recurrent gastric leiomyosarcoma (12 years later) and bilateral pulmonary chondroma is described. It is important that patients with any of the three tumors be periodically examined.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child
  • Chondroma / complications*
  • Chondroma / diagnostic imaging
  • Chondroma / pathology
  • Female
  • Humans
  • Leiomyosarcoma / complications*
  • Leiomyosarcoma / diagnostic imaging
  • Leiomyosarcoma / pathology
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Paraganglioma, Extra-Adrenal / complications*
  • Radiography
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / pathology
  • Syndrome