Objective: To investigate the current status of research on infantile cholestatic liver disease in China and future research trends.
Methods: A co-word analysis was performed in October 2016. Document retrieval and screening were performed in the Chinese databases CNKI and Wanfang Data using "cholestasis" and "infant" as key words. Excel 2010 was used to establish a co-occurrence matrix of high-frequency key words, and Ucinet 6.0 and Netdraw were used to develop a visualized network of these high-frequency key words.
Results: A total of 383 articles were included. The co-occurrence analysis showed that "infant" and "cholestasis" were the core of research in this field, and "infantile hepatitis syndrome", "neonate", "intrahepatic", "biliary atresia", "heredity and metabolism", "hepatitis", "cytomegalovirus", "jaundice", and "conjugated bilirubin" were main research topics. Most of the other articles focused on "parenteral nutrition", "hepatobiliary imaging", "gene mutation", and "liver biopsy". There were relatively few articles on surgical diagnostic techniques and treatment for this disease.
Conclusions: The research on infantile cholestatic liver disease in China focuses on etiology and differential diagnosis, and genetic diagnosis has become a hot topic in recent years. The research on treatment should be enhanced, and new diagnostic techniques are the research interest in future.
目的: 展现中国关于婴儿胆汁淤积性肝病的研究情况，描绘该领域的研究趋势，提供未来研究的可能方向。
方法: 采用共词分析法，于2016年10月以“胆汁淤积”及“婴儿”等关键词在中国知网（CNKI）及万方数据库进行文献检索及筛选，通过Excel2010建立高频关键词共现矩阵，使用Ucinet 6.0及Netdraw绘制高频关键词可视化网络图。
结果: 共纳入相关文献383篇。共现分析图显示，在整个国内研究领域中以“婴儿”“胆汁淤积”为核心，“婴儿肝炎综合征”“新生儿”“肝内”“胆道闭锁”“遗传代谢”“肝炎”“巨细胞病毒”“黄疸”“结合胆红素”为主要研究热点，其余大部分研究集中在“肠外营养”“肝胆显像”“（基因）突变”“肝活检”等方面，而关于疾病的外科诊断技术以及疾病的治疗的研究较少。
结论: 中国关于婴儿胆汁淤积性肝病的研究热点集中于病因学及鉴别诊断，基因诊断是近年来的关注点，有关治疗的研究尚有待加强，新的诊断技术是未来主要的研究方向。