Abstract
Three new glycosides (1-3) and 15 known ones (4-18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4-18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC50 values from 26.9 to 47.5 μM.
Keywords:
Nicandra physaloides; RAW 264.7; fat glycosides; inflammation; phenyl-glycosides.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Chromatography, Gas
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Fruit / chemistry*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Hydrolysis
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Macrophage Activation
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / metabolism
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RAW 264.7 Cells
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Solanaceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Glycosides
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Nitric Oxide