Breast Cancer Genetic Testing Among African Patients With Breast Cancer: Deoxyribonucleic Acid Extraction From Tumor Tissue and International Multidisciplinary Partnerships

Emmanuel Amankwaa-Frempong; Francis Agyemang Yeboah; Samuel Blay Nguah; Lisa A Newman

doi:10.1001/jamasurg.2017.1090

Breast Cancer Genetic Testing Among African Patients With Breast Cancer: Deoxyribonucleic Acid Extraction From Tumor Tissue and International Multidisciplinary Partnerships

JAMA Surg. 2017 Aug 1;152(8):800-801. doi: 10.1001/jamasurg.2017.1090.

Authors

Emmanuel Amankwaa-Frempong¹, Francis Agyemang Yeboah², Samuel Blay Nguah³, Lisa A Newman⁴

Affiliations

¹ Department of Oncology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
² Department of Molecular Medicine, School of Medical Sciences-Kwame Nkrumah, University of Science and Technology, Kumasi, Ghana.
³ Department of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
⁴ International Center for the Study of Breast Cancer Subtypes, Detroit, Michigan.

Abstract

This population-based study of Ghanian women with a family history of breast cancer analyzes breast cancer gene mutations to determine whether the triple-negative breast cancer phenotype is a risk factor for mutation carrier status.

MeSH terms

Adult
Aged
DNA / isolation & purification*
Female
Genes, BRCA1
Genes, BRCA2
Genetic Carrier Screening
Genetic Testing / methods
Genotype
Ghana
Humans
Middle Aged
Mutation / genetics*
Pedigree
Phenotype
Risk Factors
Triple Negative Breast Neoplasms / genetics*

Substances

DNA