Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens

Epidemiol Infect. 2017 Oct;145(13):2766-2769. doi: 10.1017/S0950268817001029. Epub 2017 May 18.

Abstract

The objective of this study was to determine how clinicians make use of the modern multiplex PCR assays (MPAs) to manage patients hospitalized for community-acquired pneumonia (CAP). We studied the use of MPAs in 1648 patients hospitalized for CAP over a 3-year period at the moment of the setup of the new PCR assay. We observed that the use of MPAs for the identification of multiple respiratory pathogens marks a radical change in the investigation of CAP etiology. Surprisingly, the contribution of MPAs to the medical decision-making process varies drastically according to the units of care.

Keywords: Community-acquired pneumonia; medical decision-making; multiplex PCR assay.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Clinical Decision-Making / methods*
  • Community-Acquired Infections / diagnosis
  • Community-Acquired Infections / etiology
  • Community-Acquired Infections / therapy
  • Cross-Sectional Studies
  • Female
  • France
  • Humans
  • Male
  • Middle Aged
  • Multiplex Polymerase Chain Reaction*
  • Pneumonia / diagnosis
  • Pneumonia / etiology
  • Pneumonia / therapy*
  • Retrospective Studies
  • Young Adult