Abstract
Since its conceptualization in the 1980s, the provisional matrix has often been characterized as a simple fibrin-containing scaffold for wound healing that supports the nascent blood clot and is functionally distinct from the basement membrane. However subsequent advances have shown that this matrix is far from passive, with distinct compositional differences as the wound matures, and providing an active role for wound remodeling. Here we review the stages of this matrix, provide an update on the state of our understanding of provisional matrix, and present some of the outstanding issues related to the provisional matrix, its components, and their assembly and use in vivo.
Keywords:
Fibrin; Fibrinogen; Fibronectin; Matrix Assembly; Proteoglycans; Wound Healing.
Copyright © 2017. Published by Elsevier B.V.
Publication types
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Editorial
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Historical Article
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Review
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Basement Membrane / chemistry
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Basement Membrane / metabolism
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Blood Platelets / cytology
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Blood Platelets / metabolism
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Collagen / genetics
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Collagen / metabolism
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Extracellular Matrix / chemistry
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Extracellular Matrix / genetics
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Extracellular Matrix / metabolism*
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Fibrin / genetics
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Fibrin / metabolism*
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Fibroblasts / cytology
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Fibroblasts / metabolism
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Fibronectins / genetics
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Fibronectins / metabolism*
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Gene Expression
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History, 20th Century
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History, 21st Century
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Humans
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Proteoglycans / metabolism
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Signal Transduction
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Skin / injuries
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Skin / metabolism
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Wound Healing / physiology*
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Wounds, Penetrating / history
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Wounds, Penetrating / metabolism
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Wounds, Penetrating / pathology
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Wounds, Penetrating / rehabilitation*
Substances
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Fibronectins
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Proteoglycans
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Fibrin
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Collagen