The genotypes of Orientia tsutsugamushi, identified in scrub typhus patients in northern Vietnam

Trans R Soc Trop Med Hyg. 2017 Mar 1;111(3):137-139. doi: 10.1093/trstmh/trx022.

Abstract

Background: There are an estimated one million patients with scrub typhus in the Asia-Pacific region. There are few reports describing the incidence of scrub typhus in Vietnam.

Methods: Blood samples collected from 63 patients clinically diagnosed as having scrub typhus from July 2015 to September 2016 were subjected to genotyping of Orientia tsutsugamushi.

Results and conclusions: Of these patients, 42 (67%) tested positive for O. tsutsugamushi, and the most common genotype was identified to be Karp (55%). Other genotypes, TA763, Gilliam type in Japan variant, and Kato were also found in 17%, 17% and 12% of patients, respectively. To better understand the epidemiological landscape of scrub typhus in Vietnam, a countrywide study is needed.

Accession numbers: LC110330-LC110333, LC110336-LC110351 and LC214804-LC214825.

Keywords: Genotypes; Northern Vietnam; Orientia tsutsugamushi; Scrub typhus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / genetics
  • Antigens, Bacterial / genetics
  • Bacterial Proteins / genetics*
  • Genotype
  • Genotyping Techniques / methods
  • Humans
  • Orientia tsutsugamushi / genetics*
  • Orientia tsutsugamushi / isolation & purification*
  • Phylogeny
  • Real-Time Polymerase Chain Reaction
  • Scrub Typhus / epidemiology
  • Scrub Typhus / microbiology*
  • Sequence Analysis, DNA
  • Seroepidemiologic Studies
  • Vietnam / epidemiology

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins